Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 12, Issue 26, Pages 6730-6737Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.200600370
Keywords
cyclodextrins; gene carriers; molecular recognition; polymers; polyrotaxanes
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Cyclic compounds can rotate and/or slide along a polymeric chain in a polyrotaxane structure, and the mobility of the ligands linked by the cyclic compounds is closely related to enhancing the multivalent interaction with binding sites on the receptor proteins. This concept is being exploited in more practical applications in the biomedical and pharmaceutical fields, such as a non-viral gene carriers.
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