Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 12, Issue 26, Pages 6776-6786Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.200600467
Keywords
block copolymers; click chemistry; fluorogenic; nanostructures
Categories
Funding
- NIGMS NIH HHS [5T32 GM 087850] Funding Source: Medline
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [1032267] Funding Source: National Science Foundation
Ask authors/readers for more resources
Using either nitroxide mediated polymerization (NMP) or reversible addition fragmentation transfer (RAFT) techniques, novel block copolymers that present terminal acetylenes, in the side chain of the styrenic block, were obtained with narrow poly-dispersities and targeted molecular weights. For the conversion of these acetylene-functionalized polymers to amphiphilic block copolymers, RAFT techniques were preferred. Mild protection/deprotection chemistries were employed which were compatible with the incorporation of the acetylene functionality in the hydrophobic segment. These acetylene-functionalized, Click-readied amphiphilic block copolymers were then self-assembled and cross-linked to afford shell cross-linked knedel-like (SCK) nanoparticles that contained acetylene groups in the core domain. The hydrodynamic diameters (D-h) of the block copolymer micelles and nanoparticles were determined by dynamic light scattering (DLS), and the dimensions of the nanoparticles were characterized using tapping-mode atomic force microscopy (AFM) and transmission electron microscopy (TEM). The chemical availability of the Click functionality within the core domain of the SCKs was investigated using the copper(I) -catalyzed 1,3-dipolar fluorogenic cycloaddition with a non-fluorescent 3-azidocoumarin pro-fluorophore to afford intensely fluorescent nanoparticles.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available