Journal
JOURNAL OF THEORETICAL BIOLOGY
Volume 242, Issue 1, Pages 220-236Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jtbi.2006.02.016
Keywords
immunology; mathematical modeling; anti-inflammatory cytokines; sepsis; bifurcation analysis
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Funding
- NIGMS NIH HHS [R01-GM67240] Funding Source: Medline
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The acute inflammatory response, triggered by a variety of biological or physical stresses on an organism, is a delicate system of checks and balances that, although aimed at promoting healing and restoring homeostasis, can result in undesired and occasionally lethal physiological responses. In this work, we derive a reduced conceptual model for the acute inflammatory response to infection, built up from consideration of direct interactions of fundamental effectors. We harness this model to explore the importance of dynamic anti-inflammation in promoting resolution of infection and homeostasis. Further, we offer a clinical correlation between model predictions and potential therapeutic interventions based on modulation of immunity by anti-inflammatory agents. (c) 2006 Elsevier Ltd. All rights reserved.
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