Journal
BRAIN RESEARCH
Volume 1108, Issue -, Pages 39-44Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2006.06.011
Keywords
HT22 cell; siRNA; heme oxygenase; bilirubin; oxidative stress; neuronal cell death
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To investigate the role of heme oxygenase (HO) isozymes, we used siRNA technology to suppress HO-1 expression. HO-1 siRNA-transfected HT22 cells were vulnerable to hydrogen peroxide- and 4-hydroxynonenal-induced cytotoxicity. Biliverdin and bilirubin, degradative products of heme catalyzed by HO, protected HT22 cells from the insult of these oxidative stressors. These results suggest that inducible HO-1 plays a protective role against oxidative stress in HT22 cells. (c) 2006 Elsevier B.V. All rights reserved.
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