Journal
SCIENCE
Volume 313, Issue 5792, Pages 1438-1441Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1129577
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Funding
- NIAID NIH HHS [AI45148, AI42999, T32 AI007538, AI57831, R01 AI057831] Funding Source: Medline
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Immunity-related p47 guanosine triphosphatases (IRG) play a role in defense against intracellular pathogens. We found that the murine Irgm1 (LRG-47) guanosine triphosphatase induced autophagy and generated large autolysosomal organelles as a mechanism for the elimination of intracellular Mycobacterium tuberculosis. We also identified a function for a human IRG protein in the control of intracellular pathogens and report that the human Irgm1 ortholog, IRGM, plays a role in autophagy and in the reduction of intracellular bacillary load.
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