A homologous series of eunicellin-based diterpenes from Acalycigorgia sp characterised by tandem mass spectrometry

The discovery and structure determination of a homologous series of eunicellin-based diterpenes from the gorgonian Acalycigorgia sp. is described. Extensive use was made of ID and 2D NMR data to determine the structure of the diterpene skeleton. The relative stereochemistry was confirmed via the use of NOE data in conjunction with molecular modelling. A series of homologues were identified using a combination of product and precursor ion scanning modes in tandem mass spectrometry. This powerful technique afforded excellent clarification to aid the analysis of the complex mass spectral data. (c) 2006 Elsevier Ltd. All rights reserved.