Journal
LANGMUIR
Volume 22, Issue 19, Pages 8197-8204Publisher
AMER CHEMICAL SOC
DOI: 10.1021/la060754c
Keywords
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Funding
- NIBIB NIH HHS [P41 EB002027-21, P41 EB002027, EB-002027] Funding Source: Medline
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Two different phosphonic acid monolayer films for immobilization of bioactive molecules such as the protein BMP-2 on titanium surfaces have been prepared. Monolayers of (11-hydroxyundecyl) phosphonic acid and (12-carboxydodecyl) phosphonic acid molecules were produced by a simple dipping process (the T-BAG method). The terminal functional groups on these monolayers were activated (carbonyldiimidazole for hydroxyl groups and N-hydroxysuccinimide for carboxyl groups) to bind amine-containing molecules. The reactivity of the surfaces was investigated using trifluoroethylamine hydrochloride and BMP-2. Each step of the surface modification procedure was characterized by X-ray photoelectron spectroscopy and time-of-flight secondary ion mass spectrometry.
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