Journal
BIOLOGICAL PSYCHIATRY
Volume 60, Issue 6, Pages 554-562Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2006.04.024
Keywords
schizophrenia; sustained attention; DISC1; GNPAT; haplotype association; quantitative TDT
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Funding
- NIMH NIH HHS [1R01 MH59624-01] Funding Source: Medline
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Background: The marker D1S251 of chromosome 1q42.1 showed significant association with schizophrenia in a Taiwanese sample. We used single nucleotide polymorphism (SNP) fine mapping to search for the vulnerability genes of schizophrenia. Methods: We selected 120 SNPs covering 1 Mb around D1S251 from the public database. These selected SNPs were initially validated if allele frequency was > 10%. Forty-seven validated SNPs were genotyped in 102 families with at least 2 siblings affected with schizophrenia. Results: Two SNP blocks showed significant association with schizophrenia. Block 1 (five-SNP), located between intron 2 and intron 13 of the glyceronephosphate O-acyltransferase (GNPAT) gene, showed the most significant associations using single-locus TDT (z = -2.0 7, p = .038, df = 1) and baplotype association analyses (z = -.1.99, p = .046, df = 1). Block 2 (two-SNP), located between intron 4 and intron 5 of the disrupted-in-schizophrenia 1 (DISC1) gene, also showed the most significant results in both the single-locus ( z = -3.22, p = .0013, df = 1) and haplotype association analyses (z = 3.35, p = .0008, df = 1). The association of the DISC1 gene with schizophrenia was mainly in the patient group with sustained attention deficits as assessed by the Continuous Performance Test. Conclusions: Chromosome 1q42.1 harbors GNPAT and DISC1 as candidate genes for schizophrenia, and DISCI is associated with sustained attention deficits.
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