Journal
DEVELOPMENT
Volume 133, Issue 18, Pages 3529-3537Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.02524
Keywords
wingless; snail family transcription factors; fly eye periphery
Categories
Funding
- NEI NIH HHS [R01 EY012536] Funding Source: Medline
Ask authors/readers for more resources
The periphery of the fly eye contains a number of concentrically arranged cellular specializations that are induced by Wingless (Wg) signaling from the surrounding head capsule (HC). One of these is the pigment rim ( PR), which is a thick layer of pigment cells that lies directly adjacent to the HC and completely circumscribes the rest of the retina. Many of the cells of the PR are derived from presumptive pigment cells that previously surrounded peripheral ommatidia that subsequently died. Here, we describe the Wg-elicited expression of Snail family transcription factors in the eye periphery that directs the ommatidial death and subsequent PR formation. These transcription factors are expressed only in a subset of the ommatidial cells not including the photoreceptors. Yet, the photoreceptors die and, thus, a non-autonomous death signal is released from the Snail-family-expressing cells that direct the death of the photoreceptors. In addition, Wg also elicits a similar peripheral expression of Notum, an enzyme that limits the extent of Wg signaling. Furthermore, we describe a later requirement for Snail family proteins in the 2 and 3 pigment cells throughout the main body of the eye.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available