Journal
GENES & DEVELOPMENT
Volume 20, Issue 18, Pages 2507-2512Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.1439206
Keywords
SAS; H2A.Z; H4 Lys 16 acetylation; antisilencing
Categories
Funding
- NIGMS NIH HHS [R37 GM047867] Funding Source: Medline
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The yeast SAS (Something About Silencing) complex and the histone variant H2A.Z have both previously been linked to an antisilencing function at the subtelomeric regions. SAS is an H4 Lys 16-specific histone acetyltransferase complex. Here we demonstrate that the H4 Lys 16 acetylation by SAS is required for efficient H2A.Z incorporation near telomeres. The presence of H4 Lys 16 acetylation and H2A.Z synergistically prevent the ectopic propagation of heterochromatin. Overall, our data suggest a novel antisilencing mechanism near telomeres.
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