Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 16, Issue 18, Pages 4889-4892Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2006.06.058
Keywords
peptide deformylase; S. aureus; macrolactin; antibacterial
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A new 24-membered ring lactone, macrolactin N, was isolated from a culture broth of Bacillus subtilis and its structure was established by various spectral analysis. Macrolactin N inhibited Staphylococcus aureus peptide deformylase with an IC50 value of 7.5 mu M and also showed antibacterial activity against Escherichia coli and S. aureus. (c) 2006 Elsevier Ltd. All rights reserved.
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