4.4 Article

Palladium(II)-catalyzed addition of arylboronic acid to nitriles

Journal

TETRAHEDRON LETTERS
Volume 47, Issue 38, Pages 6765-6768

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2006.07.074

Keywords

palladium; nitrile; bipyridine; nucleophilic addition; ligand

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The addition of arylboronic acid to nitriles catalyzed by palladium(II) species in the presence of bipyridine as the ligand was developed. The use of bipyridine is crucial for changing the properties of arylpalladium species from more electrophilic to more nucleophilic making the reaction possible. (c) 2006 Elsevier Ltd. All rights reserved.

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