4.5 Article

Efficient oxidative synthesis of 2-oxazolines

Journal

SYNTHESIS-STUTTGART
Volume -, Issue 18, Pages 2996-3002

Publisher

GEORG THIEME VERLAG KG
DOI: 10.1055/s-2006-950198

Keywords

amino alcohols; oxidative coupling; oxazolines; oxazolidines; N-bromosuccinimide

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New methodology for the synthesis of variously substituted 2-oxazolines and one dihydrooxazine using aldehydes, amino alcohols, and N-bromosuccinimide as an oxidizing agent is described. This one-pot synthesis is characterized by mild reaction conditions, broad scope, high yields, and its preparative simplicity.

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