Journal
JOURNAL OF ETHNOPHARMACOLOGY
Volume 107, Issue 2, Pages 169-174Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.jep.2006.02.021
Keywords
anti-inflammatory activity; antinociceptive activity; 12-O-tetradecanoyl-13-acetate (TPA); Maclura pomifera; scandenone; auriculasin; prenylated isoflavone
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The aqueous, ethanolic and chloroform extracts and two prenylated isoflavones: scandenone (I) and auriculasin (II), isolated from the fruits of Maclura pomifera (Rafin.) Schneider, were investigated for their in vivo anti-inflammatory and antinociceptive activity. For the anti-inflammatory activity, both carrageenan-induced hind paw edema and 12-O-tetradecanoyl-13-acetate (TPA)-induced mouse ear edema models and for the antinociceptive activity, p-benzoquinone-induced abdominal constriction test were used. Scandenone, the chloroform and the ethanolic extracts were shown to possess antinociceptive activity and anti-inflammatory activity on carrageenan-induced hind paw edema model at 100 mg/kg dose. The same compound and the extract were also found to be highly active in (TPA)-induced mouse ear edema model whereas auriculasin and the H2O extract showed to be inactive in all of the assays. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
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