Journal
NEURON
Volume 51, Issue 6, Pages 703-714Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2006.07.027
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Funding
- NIA NIH HHS [R21 AG024447] Funding Source: Medline
- NINDS NIH HHS [K08 NS054811-01, K08 NS054811] Funding Source: Medline
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Alzheimer's disease (AD) may result from the accumulation of amyloid-beta (A beta) peptides in the brain. The cysteine protease cathepsin B (CatB) is associated with amyloid plaques in AD brains and has been suspected to increase AD production. Here, we demonstrate that CatB actually reduces levels of AD peptides, especially the aggregation-prone species A beta 1-42, through proteolytic cleavage. Genetic inactivation of CatB in mice with neuronal expression of familial AD-mutant human amyloid precursor protein (hAPP) increased the relative abundance of A beta 1-42, worsening plaque deposition and other AD-related pathologies. Lentivirus-mediated expression of CatB in aged hAPP mice reduced preexisting amyloid deposits, even thioflavin S-positive plaques. Under cell-free conditions, CatB effectively cleaved A beta 1-42, generating C-terminally truncated A beta peptides that are less amyloidogenic. Thus, CatB likely fulfills antiamyloidogenic and neuroprotective functions. Insufficient CatB activity might promote AD; increasing CatB activity could counteract the neuropathology of this disease.
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