Phenolic glycosides with antioxidant activity from the stem bark of Populus davidiana

Phytochemical study on the EtOAc-soluble fraction of the stem bark of Populus davidiana resulted in the isolation of 10 phenolic glycosides (1-10), which were identified on the basis of physicochemical and spectroscopic analyses. Among these, three new compounds, populosides A-C (1-3), were determined to be 2-coumaroylmethyl-4-hydroxyphenyl-beta- D-glucopyranoside, 2-coumaroylmethylphenyl-beta-D-glucopyranoside, and 2-feruoylmethylphenyl-beta-D-glucopyranoside, respectively. Compounds 1-10 were tested for their radical scavenging activity against an azo radical, ABTS(center dot+). Of these, populosides A- C (1-3), populoside ( 4), grandidentatin ( 8), salireposide ( 9), and coumaroyl-beta-D-glucoside ( 10) exhibited antioxidant activity in this assay.