Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1128, Issue 1-2, Pages 273-281Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.chroma.2006.06.053
Keywords
sequential uniform design; CE fingerprint; Ginkgo biloba; local overlap index; two-dimensional data
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A sequential procedure for the method of development of fingerprints based on a uniform design approach has been described in this paper. The sequential uniform design is used to reach the global optimum for a separation. The procedure is illustrated through developing the fingerprint of a Ginkgo biloba extract by capillary electrophoresis (CE) with diode array detection (DAD). The local overlap index (LOVI) is proposed as a criterion to evaluate the separation quality of two-dimensional hyphenated data in the optimization process. The successful application of the described techniques, including a sequential procedure, the CE-DAD hyphenated method and the LOVI criterion, shows their practicality in the fingerprint development of herbal medicines. However, some critical remarks on their use can also be made. (c) 2006 Elsevier B.V. All rights reserved.
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