Journal
SCIENCE
Volume 313, Issue 5794, Pages 1775-1781Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1130408
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Funding
- NINDS NIH HHS [R01-NS051305-01A1] Funding Source: Medline
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Sleep is a vital, evolutionarily conserved phenomenon, whose function is unclear. Although mounting evidence supports a role for sleep in the consolidation of memories, until now, a molecular connection between sleep, plasticity, and memory formation has been difficult to demonstrate. We establish Drosophila as a model to investigate this relation and demonstrate that the intensity and/or complexity of prior social experience stably modifies sleep need and architecture. Furthermore, this experience-dependent plasticity in sleep need is subserved by the dopaminergic and adenosine 3', 5'-monophosphate signaling pathways and a particular subset of 17 long-term memory genes.
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