Journal
CHEMICO-BIOLOGICAL INTERACTIONS
Volume 162, Issue 3, Pages 195-211Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.cbi.2006.07.001
Keywords
carboxylesterases; function; drug metabolism; gene expression; molecular structure; regulation; enzyme induction; novel nomenclature and classification
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This review covers current developments in molecular-based studies of the structure and function of carboxylesterases. To allay the confusion of the classic classification of carboxylesterase isozymes, we have proposed a novel nomenclature and classification of mammalian carboxylesterases on the basis of molecular properties. In addition, mechanisms of regulation of gene expression of carboxylesterases by xenobiotics and involvement of carboxylesterase in drug metabolism and enzyme induction are also described. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
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