Journal
NEUROLOGY
Volume 67, Issue 6, Pages 1071-1073Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/01.wnl.0000237334.69665.92
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Long-term morbidity from Guillain-Barre syndrome (GBS) is caused by axonal damage. This prospective study demonstrated that neurofilaments (NfHs), a biomarker for axonal damage, were of prognostic value in GBS. CSF NfH levels correlated with the F score and Medical Research Council summed score and were higher in patients with neurophysiologic evidence of axonal degeneration compared to those without. Pathologically high CSF NfH levels (> 0.73 ng/mL) predicted worse motor and functional outcome.
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