Journal
BRAIN RESEARCH
Volume 1112, Issue -, Pages 99-105Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2006.07.014
Keywords
hypoxic-ischemic encephalopathy; transplantation; neuronal differentiation; migration
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Funding
- NHLBI NIH HHS [HL70143] Funding Source: Medline
- NINDS NIH HHS [NS37556, NS02198] Funding Source: Medline
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Hypoxic-ischemic encephalopathy (HIE) in neonates results in long-term disabilities. Stem cell therapy may offer an attractive treatment for HIE. Multipotent astrocytic stem cells (MASCs) from mice transplanted into a rat model of hypoxia-ischemia (HI) survived the transplantation and showed signs of migration towards the injured cortex. Some MASCs around the injured cortex differentiated into neuronal and astrocytic phenotypes. MASCs transplanted into non-ischemic pups survived but retained their astrocytic phenotype. These data suggest that transplanted MASCs can survive and differentiate into neurons and astrocytes in the post-injury milieu of the neonatal brain injured by HI. (c) 2006 Elsevier B.V. All rights reserved.
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