Journal
ORGANIC LETTERS
Volume 8, Issue 20, Pages 4609-4612Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol061922v
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Hybrid compounds of macrosphelides and epothilones, both of which are natural macrolides having a 16-membered skeleton, were designed and synthesized using a ring-closing metathesis (RCM) strategy. Some of these hybrids were found to exhibit notable apoptosis-inducing activity against human lymphoma cells with higher potency than parent natural macrosphelides, and to be a promising lead compound for development of a new antitumor agent.
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