Journal
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
Volume 153, Issue 2, Pages 115-125Publisher
ELSEVIER
DOI: 10.1016/j.resp.2005.09.013
Keywords
ventilation; thermoregulation; hypoxia; adenosine; preoptic area; rats
Categories
Ask authors/readers for more resources
The present study was undertaken to investigate adenosine as a simultaneous mediator of hypoxia-induced hyperventilation and regulated hypothermia in the anteroventral preoptic region (AVPO).the thermointegrative region of the central nervous system (CNS). Accordingly, we predicted that injection of aminophylline and DPCPX, non-selective and A, receptor antagonists, respectively, into the AVPO would exacerbate the ventilatory response and lessen the drop in body temperature (T-b) caused by hypoxia. We measured ventilation (V) and Tb of conscious Wistar rats before and after AVPO injection of aminophylline (I and 10 mu g/100nL) or DPCPX (17.5 and 175ng/100nL), or their respective vehicles, followed by 30 min of hypoxia (7% O-2)Vehicles and the lower doses of both antagonists had no effect on V and T-b during normoxia or hypoxia. The higher doses of arninophylline and DPCPX increased (P < 0.05) the hypoxia-induced hyperventilation, whereas the drop in T-b elicited by hypoxia was attenuated (P < 00.05) by DPCPX only. This higher DPCPX dose also increased T-b during normoxia. The present data is consistent with the notion that adenosine plays an inhibitory role in respiratory and metabolic regulation, in a way that A, receptors stimulation in the AVPO inhibits ventilatory drive during hypoxia and tonically modulates basal Tb. (c) 2005 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available