Journal
SCIENCE
Volume 313, Issue 5795, Pages 1935-1942Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1131127
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- MRC [MC_U105184332] Funding Source: UKRI
- Medical Research Council [MC_U105184332] Funding Source: researchfish
- Medical Research Council [MC_U105184332] Funding Source: Medline
- NIGMS NIH HHS [GM67624] Funding Source: Medline
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The crystal structure of the bacterial 70S ribosome refined to 2.8 angstrom resolution reveals atomic details of its interactions with messenger RNA ( mRNA) and transfer RNA ( tRNA). A metal ion stabilizes a kink in the mRNA that demarcates the boundary between A and P sites, which is potentially important to prevent slippage of mRNA. Metal ions also stabilize the intersubunit interface. The interactions of E-site tRNA with the 50S subunit have both similarities and differences compared to those in the archaeal ribosome. The structure also rationalizes much biochemical and genetic data on translation.
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