Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 348, Issue 3, Pages 1101-1106Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2006.07.158
Keywords
HIV-1 Vpr; screening; damnacanthal; apoptosis; G(2) arrest
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Funding
- NCI NIH HHS [R01 CA070018, CA070018-10] Funding Source: Medline
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Viral protein R (Vpr), one of the human immunodeficiency virus type I (HIV-1) accessory proteins, contributes to multiple cytopathic effects, Q, cell cycle arrest and apoptosis. The mechanisms of Vpr have been intensely studied because it is believed that they underlie HIV-1 pathogenesis. We here report a cell-based small molecule screen on Vpr induced cell death in the context of HIV-1 infection. From the screen of 504 bioactive compounds, we identified damnacanthal (Dam), a component of noni fruit, as an inhibitor of Vpr induced cell death. Our studies illustrate a novel efficient platform for drug discovery and development in anti-HIV therapy which should also be applicable to other viruses. (c) 2006 Elsevier Inc. All rights reserved.
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