Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 281, Issue 39, Pages 28494-28498Publisher
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.C600197200
Keywords
-
Categories
Funding
- NIDDK NIH HHS [R01 DK053813, R01 DK053813-10, R01 DK53813] Funding Source: Medline
Ask authors/readers for more resources
HFE and transferrin receptor 2 (TFR2) are membrane proteins integral to mammalian iron homeostasis and associated with human hereditary hemochromatosis. Here we demonstrate that HFE and TFR2 interact in cells, that this interaction is not abrogated by disease-associated mutations of HFE and TFR2, and that TFR2 competes with TFR1 for binding to HFE. We propose a new model for the mechanism of iron status sensing that results in the regulation of iron homeostasis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available