Journal
FREE RADICAL RESEARCH
Volume 40, Issue 10, Pages 1095-1104Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10715760600796498
Keywords
green tea; pomegranate; polyphenols; prostate cancer; chemoprevention
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Funding
- NCI NIH HHS [R01 CA 78809, R01 CA 101039] Funding Source: Medline
- NIDDK NIH HHS [P50 DK065303-01] Funding Source: Medline
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Prostate cancer (PCa) is the most common non-cutaneous cancer diagnosed in North America with similar trends in many Western countries. Geographic, epidemiological and laboratory studies suggest a role for dietary constituents in the etiology as well as prevention of PCa. The rising incidence of PCa in several countries appears to be coincidental with adoption of western lifestyle. Increase in the incidence of PCa has also been found in Asian populations migrating to the west. These facts give numerous leads to explore testable PCa prevention strategies. There is growing evidence in support of use of dietary ingredients in prevention and treatment of PCa. While substantial data exists in favor of use of polyphenols from tea as PCa chemopreventive agent, interest in anti-cancer properties of polyphenols from pomegranate has recently emerged. This review summarizes current literature on the effects of polyphenols from green tea and pomegranate against PCa.
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