Journal
PEPTIDES
Volume 27, Issue 10, Pages 2385-2404Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.peptides.2006.04.024
Keywords
neurotensin; dopamine; schizophrenia; antipsychotic drugs; drugs of abuse; Parkinson's disease
Funding
- NIMH NIH HHS [MH-39415] Funding Source: Medline
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Neurotensin (NT), an endogenous brain-gut peptide, has a close anatomical and functional relationship with the mesocorticolimbic and neostriatal dopamine system. Dysregulation of NT neurotransmission in this system has been hypothesized to be involved in the pathogenesis of schizophrenia. Additionally, NT containing circuits have been demonstrated to mediate some of the mechanisms of action of antipsychotic drugs, as well as the rewarding and/or sensitizing properties of drugs of abuse. NT receptors have been suggested to be novel targets for the treatment of psychoses or drug addiction. (c) 2006 Elsevier Inc. All rights reserved.
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