Journal
EUROPEAN JOURNAL OF IMMUNOLOGY
Volume 36, Issue 10, Pages 2681-2690Publisher
WILEY
DOI: 10.1002/eji.200636220
Keywords
CD8 T cells; dendritic cells; gamma delta T cells; IFN-gamma; Mycobacterium tuberculosis
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gamma delta T cells and dendritic cells are quickly recruited to the lungs shortly after intranasal vaccination with BCG, but the functional in vivo interplay between these two cell populations and its role in the induction of adaptive immune responses is unclear. Using TCR-deficient mice and bone marrow chimeras, we show here that gamma delta T cells provide a non-redundant early source of IFN-gamma in vivo, which enhances IL-12 production by lung dendritic cells. The in vivo-conditioned dendritic cells, in turn, prime a more efficient lung CD8 T cell response against Mycobacterium tuberculosis. Thus, strategies exploiting gamma delta T cell function and IFN-gamma production could be valuable for the design and testing of mucosal vaccines.
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