Journal
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
Volume 32, Issue 5, Pages 483-491Publisher
WILEY
DOI: 10.1111/j.1365-2990.2006.00745.x
Keywords
autism; columns; frontal cortex
Categories
Funding
- NIDA NIH HHS [DA13137] Funding Source: Medline
Ask authors/readers for more resources
Cell minicolumns were shown to be narrower in frontal regions in brains of autistic patients compared with controls. This was not found in primary visual cortex. Within the frontal cortex, dorsal and orbital regions displayed the greatest differences while the mesial region showed the least change. We also found that minicolumns in the brain of a 3-year-old autistic child were indistinguishable from those of the autistic adult in two of three frontal regions, in contrast to the control brains. This may have been due to the small size of the columns in the adult autistic brain rather than to an accelerated development. The presence of narrower minicolumns supports the theory that there is an abnormal increase in the number of ontogenetic column units produced in some regions of the autistic brain during corticoneurogenesis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available