Journal
NEUROSCIENTIST
Volume 12, Issue 5, Pages 435-441Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/1073858406290375
Keywords
autistic disorder/pathology; child development disorders; pervasive; neocortex; neuropil; pyramidal cells
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Funding
- NIMH NIH HHS [MH 61606, MH 69991, MH 62654] Funding Source: Medline
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Autism is a condition manifested as abnormalities of relatedness, communication, range of interests, and repetitive behaviors. Despite alarming prevalence estimates and exhortations to research, little is known regarding its pathophysiology. Recent reports of a putative minicolumnopathy explain changes in brain size, gray/white matter ratios, and interareal connectivity. This article summarizes possible links between mini-columns and other topics-cortical modularity, age of onset, gliosis, and genetics-relevant to the pathophysiology of autism.
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