Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 14, Issue 19, Pages 6539-6547Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2006.06.013
Keywords
L-limonene; L-carvone; synthesis; antiproliferative effect; ERK; prostate cancer
Ask authors/readers for more resources
Thirty-one novel derivatives of carvone, carveol, and limonene were designed and synthesized using L-carvone as a starting material via chlorination, nucleophilic substitution, and reduction. The structures of these derivatives were characterized by MS and H-1 NMR. The antiproliferative effect was evaluated in human prostate cancer LNCaP cells. L-Carvone, L-carveol, and L-liruonene were weak cell growth inhibitors and introduction of 4-(2-methoxyphenyl)piperazine to carvone, carveol or limonene significantly increased their antiproliferative effect. The antiproliferative effect was correlated with ERK activation and p21(waf1) induction. (c) 2006 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available