Journal
AIDS RESEARCH AND HUMAN RETROVIRUSES
Volume 22, Issue 10, Pages 979-984Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/aid.2006.22.979
Keywords
-
Categories
Funding
- NCRR NIH HHS [G12 RR03050-19, G12RR03050, G12 RR003050] Funding Source: Medline
Ask authors/readers for more resources
Approximately 8% of the human genome sequence is composed by human endogenous retroviruses ( HERVs), most of which are defective. HERV-K(HML-2) is the youngest and most active family and has maintained some proviruses with intact open reading frames (ORFs) that code for viral proteins that may assemble into viral particles. Many HERV-K(HML-2) sequences are polymorphic in humans ( present in some individuals but not in others) and probably many others may be unfixed ( not inserted permanently in a specific chromosomal location of the human genome). In the present study HIV-1 and HCV-1-positive plasma samples were screened for the presence of HERV-K(HML-2) RNA in an RT-PCR using HERV-K pol specific primers. HERV-K(HML-2) viral RNA sequences were found almost universally in HIV-1(+) plasma samples (95.33%) but were rarely detected in HCV-1 patients (5.2%) or control subjects (7.69%). Other HERV-K(HML-2) viral segments of the RNA genome including gag, prt, and both env regions, surface (su), and transmembrane (tm) were amplified from HERV-K pol-positive plasma of HIV-1 patients. Type 1 and type 2 HERV-K(HML-2) viral RNA genomes were found to coexist in the same plasma of HIV-1 patients. These results suggest the HERV-K(HML-2) viral particles are induced in HIV-1-infected individuals.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available