Lipoxidation-derived reactive carbonyl species as potential drug targets in preventing protein carbonylation and related cellular dysfunction

Reactive carbonyl species generated by lipid peroxidation are involved in several human diseases and may represent a novel drug target. RCS therefore represent a new biological target for drug discovery. The reaction mechanisms and structural features characterising effective alclehyde-sequestering agents are highlighted, as are the fundamental biochemical and pharmacological screening tools to be applied in the development of RCS scavengers.