Journal
SPRINGER SEMINARS IN IMMUNOPATHOLOGY
Volume 28, Issue 2, Pages 109-117Publisher
SPRINGER
DOI: 10.1007/s00281-006-0033-4
Keywords
-
Categories
Ask authors/readers for more resources
The identification of genes for autoimmune diseases is just the first step towards our understanding of disease pathogenesis. In investigating how mutations, deletions or other types of polymorphic defects occur, it is important to determine the pathways and the mechanisms through which susceptibility leads to disease. In this review I touch on three examples of studies that have attempted to understand the mechanisms of genetic susceptibility in three genes identified recently for systemic lupus erythematosus: PDCD1, PTPN22 and IRF5. We are just beginning to comprehend and much needs to be done.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available