Journal
CELLULAR SIGNALLING
Volume 18, Issue 10, Pages 1549-1559Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cellsig.2006.03.009
Keywords
signalling; 7TM receptors; biosynthesis; trafficking
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Recent studies have shown that 7-transmembrane receptors (7TM-Rs), their associated signalling molecules and scaffolding proteins are often constitutively associated under basal conditions. These studies highlight that receptor ontogeny and trafficking are likely to play key roles in the determination of both signalling specificity and efficacy. This review highlights information about how 7TM-Rs and their associated signalling molecules are trafficked to the cell surface as well as other intracellular destinations. (c) 2006 Elsevier Inc. All rights reserved.
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