Journal
BONE
Volume 39, Issue 4, Pages 938-945Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.bone.2006.04.016
Keywords
VDR; BsmI; TaqI; genotype; fracture; meta-analysis
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Introduction: Fracture is the major clinical outcome of osteoporosis. The vitamin D receptor (VDR) gene is thought to be a candidate gene for osteoporosis. Many genetic studies have suggested an association of VDR polymorphisms and osteoporosis, but evidence remains conflicting. Materials and methods: We searched published studies from 1996 to September 2005 through PubMed and evaluated the genetic effect of the BsmI and TaqI polymorphism of VDR on fracture risk in a meta-analysis. Thirteen studies with a total of 20 eligible comparisons (1632 fracture cases and 5203 controls) were analyzed with fixed and random effects models. Result: No evidence of relationship between the VDR BsmI or TaqI polymorphism and fracture risk was observed with any genetic model. The odds ratio (95% confidence interval) of b-allele versus B-allele was 0.98 (0.86-1.12) with random effects calculations. There was significant between-study heterogeneity. Small studies did not differ significantly from larger ones. Conclusion: No relationship of the VDR BsmI or TaqI polymorphism and fracture risk was found in the meta-analysis of published data. (c) 2006 Elsevier Inc. All rights reserved.
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