Journal
CANADIAN JOURNAL OF CHEMISTRY
Volume 84, Issue 10, Pages 1416-1425Publisher
CANADIAN SCIENCE PUBLISHING
DOI: 10.1139/V06-116
Keywords
extracoordinate chiral silane; C-2-symmetry; enantioselectivity; Lewis acid titanium catalysis
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Extracoordinate chiral hydrosilanes were generated in situ from triethoxysilane and a C-2-symmetric ligand derived from bisproline 7. In the presence of a catalytic amount of ligand 7, prochiral ketones were reduced in moderate yield with moderate enantioselectivity (up to 64% ee). Alternatively, TiF4 complexes of 7 were used to provide higher enantioselectivity and with improved yields. The copper complex of ligand 7 and Si-29 NMR data provide some Guidance as to the key factors responsible for the observed reactivity at the silicon and at the ligand centre.
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