Journal
SLEEP
Volume 29, Issue 10, Pages 1321-1325Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/sleep/29.10.1321
Keywords
REM sleep behavior disorder; Alzheimer disease; REM sleep without atonia; polysomnography; tauopathy; synucleinopathy
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Study Objective: To determine the frequency of rapid eye movement (REM) sleep behavior disorder (RBD) and REM sleep without atonia among patients with Alzheimer disease and control subjects. Design: Overnight polysomnography. Settings: Sleep laboratory. Patients: Fifteen patients with probable Alzheimer disease (mean age SD, 70.2 +/- 5.6) and 15 age-matched healthy control subjects (mean age +/- SD, 67.9 +/- 5.4). Intervention: N/A. Results: Four patients with Alzheimer disease presented REM sleep without atonia. One of these patients had all the polysomnographic features of RBD, including behavioral manifestations during REM sleep. Conclusion: RBD is rare, but REM sleep without atonia is relatively frequent in patients with probable Alzheimer disease, a tauopathy.
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