Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 7, Issue 10, Pages 713-726Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm2026
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Funding
- NIGMS NIH HHS [R01 GM059609-07, R01 GM059609] Funding Source: Medline
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The cellular functions of the actin cytoskeleton require precise regulation of both the initiation of actin polymerization and the organization of the resulting filaments. The actin-related protein-2/3 (ARP2/3) complex is a central player in this regulation. A decade of study has begun to shed light on the molecular mechanisms by which this powerful machine controls the polymerization, organization and recycling of actin-filament networks, both in vitro and in the living cell.
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