Journal
JOURNAL OF VIROLOGY
Volume 80, Issue 19, Pages 9899-9904Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00640-06
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Funding
- Wellcome Trust Funding Source: Medline
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The role of NF-kappa B in regulating human cytomegalovirus (HCMV) replication and gene transcription remains controversial. Multiple, functional NF-kappa B response elements exist in the major immediate-early promoter (MIEP) enhancer of HCMV, suggesting a possible requirement for this transcription factor in lytic viral replication. Here we demonstrate by generating and analyzing HCMVs with alterations in the MIEP-enhancer that, although this region is essential for HCMV growth, none of the four NF-kappa B response elements contained within the enhancer are required for MIE gene expression or HCMW replication in multiple cell types. These data reveal the robustness of the regulatory network controlling the MIEP enhancer.
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