Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 7, Issue 10, Pages 727-738Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm2025
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Communication between compartments of the exocytic and endocytic pathways in eukaryotic cells involves transport carriers-vesicles and tubules-that mediate the vectorial movement of cargo. Recent studies of transport-carrier formation in the early secretory pathway have provided new insights into the mechanisms of cargo selection by coat protein complex-II (COPII) adaptor proteins, the construction of cage-protein scaffolds and fission. These studies are beginning to produce a unifying molecular and structural model of coat function in the formation and fission of vesicles and tubules in endomembrane traffic.
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