Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 18, Issue 5, Pages 533-540Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2006.08.010
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Funding
- NIGMS NIH HHS [T32-GM07507] Funding Source: Medline
- NINDS NIH HHS [NS42228] Funding Source: Medline
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Repulsive signaling plays a prominent role in regulating cell-cell interactions and is fundamental to multiple developmental processes. A proper balance between repulsion from and adhesion to other cells or the extracellular matrix is also important. Semaphorin-Plexin and ephrin-Eph ligand-receptor pairs compose two major repulsive signaling systems. Recent advances have elucidated mechanisms by which Semaphorin-Plexin and ephrin-Eph signaling control repulsion versus adhesion. Semaphorins act through a complex signaling pathway to inhibit integrin-mediated adhesion, allowing cell repulsion. Ephrin-Eph interactions can directly mediate cell adhesion and several mechanisms control whether ephrin-Eph binding and signaling induces repulsion or adhesion.
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