Journal
MITOCHONDRION
Volume 6, Issue 5, Pages 225-234Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.mito.2006.07.006
Keywords
mitochondria; apoptosis; necrosis; Bcl-2; mitochondrial permeability transition; reactive oxygen species; cyclosporine A
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The mitochondrial permeability transition (MPT) is a non-selective inner membrane permeabilization that occurs in response to increased calcium load and redox stress. Currently, two models of the MPT exist including the, largely hypothetical, native proteinaceous pore model and the oxidized inner membrane protein model which may reflect the extremes in a continuum of changes that occur to the inner membrane prior to its permeabilization. Here I discuss evidence that the MPT per se leads to necrosis, but not cytochrome c release and apoptosis. However, data also suggest that signaling crosstalk between the MPT and Bcl-2 family proteins occurs indicating an important role for the MPT in apoptosis. (c) 2006 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
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