Journal
JOURNAL OF DENTAL RESEARCH
Volume 85, Issue 10, Pages 950-954Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/154405910608501016
Keywords
chlorhexidine; chlorhexidine diacetate; controlled release; UDMA-TEGDMA resin; pH-dependent release
Categories
Funding
- NIDCR NIH HHS [DE 13412, R01 DE013412-01A1, R01 DE013412] Funding Source: Medline
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Chlorhexidine salts are available in various formulations for dental applications. This study tested the hypothesis that the release of chlorhexidine from a urethane dimethacrylate and triethylene glycol dimethacrylate resin system can be effectively controlled by the chlorhexidine diacetate content and pH. The filler concentrations were 9.1, 23.1, or 33.3 wt%, and the filled resins were exposed to pH 4 and pH 6 acetate buffers. The results showed that Fickian diffusion was the dominant release mechanism. The rates of release were significantly higher in pH 4 buffer, which was attributed to the increase of chlorhexidine diacetate solubility at lower pH. The higher level of filler loading reduced the degree of polymerization, leading to a greater loss of organic components and higher chlorhexidine release rates.
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