Journal
EXPERIMENTAL GERONTOLOGY
Volume 41, Issue 10, Pages 922-927Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exger.2006.06.058
Keywords
life span; DAF-16; FOXO; nematode aging; stress resistance; dauer larvae; Caenorhabditis elegans
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Funding
- NIA NIH HHS [AG12689] Funding Source: Medline
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The Forkhead Box O transcription factor DAF-16 regulates genes affecting dauer larva formation and adult life span. Expression profiling and genome-wide searches for DAF-16 binding sites in gene regulatory regions have identified thousands of potential DAF-16 targets. Some of these genes have been shown to alter longevity when their expression is attenuated by RNAi treatment. DAF-16 also associates with other transcription factors, allowing combinatorial modulation of gene expression. Although extensive descriptions of the gene network regulated by DAF-16 have been attempted, there remain many gaps in the understanding of how DAF-16 regulates dauer formation and longevity. (c) 2006 Elsevier Inc. All rights reserved.
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