Journal
NATURE STRUCTURAL & MOLECULAR BIOLOGY
Volume 13, Issue 10, Pages 945-946Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb1144
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Fringe proteins are beta 1,3-N-acetylglucosaminyltransferases that modify Notch receptors, altering their ligand-binding specificity to regulate Notch signaling in development. We present the crystal structure of mouse Manic Fringe bound to UDP and manganese. The structure reveals amino acid residues involved in recognition of donor substrates and catalysis, and a putative binding pocket for acceptor substrates. Mutations of several invariant residues in this pocket impair Fringe activity in vivo.
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