Journal
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
Volume 26, Issue 10, Pages 2345-2350Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/01.ATV.0000240517.69201.77
Keywords
atherosclerosis; coronary artery disease; inflammation; mannose-binding lectin
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Funding
- Medical Research Council [MC_U106179471, G0401527] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
- Medical Research Council [G0401527, MC_U106179471] Funding Source: researchfish
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Objective - To determine the association between serum levels of mannose-binding lectin (MBL) and the risk of future coronary artery disease ( CAD) in apparently healthy men and women. Methods and Results - We performed a prospective case-control study among apparently healthy men and women nested in the EPIC-Norfolk cohort. Baseline concentrations of MBL were measured in serum samples of 946 patients who experienced a myocardial infarction or died of CAD during follow-up, and 1799 matched controls who remained free of CAD. Among men, median MBL levels were 1.63 ng/mL (interquartile range [IQR]: 0.59 to 3.80) in cases and 1.20 ng/mL (IQR: 0.48 to 3.37) in controls. Among women, median MBL levels were 1.02 ng/mL (IQR: 0.43 to 2.95) in cases and 1.01 ng/mL (IQR: 0.43 to 2.94) in controls. After adjustment, the odds ratio in men for future CAD was 1.59 (95% confidence interval [CI]: 1.09 to 2.32; P for linearity = 0.01) for those in the highest quartile compared with those in the lowest quartile. In women no such relation was observed. Conclusions - Elevated levels of MBL are associated with an increased risk of future CAD in apparently healthy men but not in women. The sex difference merits further exploration.
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