Journal
CYTOKINE & GROWTH FACTOR REVIEWS
Volume 17, Issue 5, Pages 349-366Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2006.07.003
Keywords
IL-2; IL-2 receptor; transcription; gamma c; XSCID
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Funding
- Intramural NIH HHS Funding Source: Medline
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Interleukin-2 was discovered in 1976 as a T-cell growth factor. It was the first type I cytokine cloned and the first for which a receptor component was cloned. Its importance includes its multiple actions, therapeutic potential, and lessons for receptor biology, with three components differentially combining to form high, intermediate, and low-affinity receptors. IL-21ka and IL-2R beta, respectively, are markers for double-negative thymocytes and regulatory T-cells versus memory cells. gamma(c) which is shared by six cytokines, is mutated in patients with X-linked severe-combined immunodeficiency. We now cover an under-reviewed area-the regulation of genes encoding IL-2 and lL-2R components, with an effort to integrate/explain this knowledge. Published by Elsevier Ltd.
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