Journal
BIOSYSTEMS
Volume 86, Issue 1-3, Pages 46-52Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biosystems.2006.02.016
Keywords
hippocampus; theta oscillation; compartmental modeling; reaction kinetics; systems description
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A novel way of computational modeling by integrating compartmental neural techniques and detailed kinetic description of pharmacological modulation of transmitter-receptor interaction is offered as a method to test the electro-physiological and behavioral effects of potential drugs. Even more, an inverse method is suggested as a method for controlling a neural system to realize a prescribed temporal pattern. Generation and pharamcological modulation of theta rhythm in area CA1 of the hippocampus related to anxiety is analyzed. Integrative modeling might help to find positive allosteric modulators of alpha(1) subunits as potential candidates for being selective anxyolitics. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
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